This is a list of those killed by Sam and Dean in the TV series, Supernatural.
For unnamed demons, etc., only significant ones to be listed.
Season 1
- Wendigo - Shot by Dean with a flare gun
- Mary Worthington/Bloody Mary - Showed her own reflection in a mirror by Dean, who then shattered the mirror
- Serial Killer Shapeshifter - Shot in the heart by Dean with a silver bullet
- Jacob Karns/The Hookman - Destroyed when the silver necklace that made his hook was thrown into the furnace by Dean.
- Dr. Sanford Ellicott spirit - Destroyed when his remains were burned by Dean
- Rawhead - Electrocuted by Dean with a taser while standing in a puddle of water
- Cyrus Dorian spirit - Tricked by Dean (under instructions from Sam) into driving to where a church once stood (which Cyrus himself burned down), and was destroyed
- Mordechai Murdoch - Killed when Dean burned down the house, as without the house part of the legend, he could no longer exist (he was a Tulpa, and manifested from what people believed)
- Dr. Hydeker - Shot between the eyes by Dean with a silver bullet
- Melanie Merchant spirit - Destroyed when Dean burned a doll that had some of her hair in it
- Beau - Decapitated by Dean
- Tom - Shot in the head by Dean with the Colt
Season 2
- Barry Papazian - Stabbed from behind by Sam with a brass pipe from an organ
- Conrad - Decapitated by Dean with an electric saw
- Angela Mason (zombified) - Stabbed inside her coffin by Dean with a stake
- Mr. Tanner - Shot three times by Dean
- Beverly Tanner - Shot three times by Dean.
- Nurse Pamela Clayton - Shot in the back three times by Dean
- Robbery Shapeshifter - Stabbed by Dean with a silver blade
- Jonah Greely spirit - Destroyed when Sam burned his corpse
- Glen - Shot three times by Dean
- Madison - Shot by Sam
- Nurse Glockner spirit - Destroyed when Sam and Dean burned her remains
- Djinn - Stabbed by Dean with a silver knife
- Jake Talley - Shot multiple times by Sam
- Azazel - Shot in the heart by Dean with the Colt
Season 3
- Changeling mother - Burned to death by Sam with a flamethrower
- Father Gil (demon) - Shot by Sam with the Colt
- Casey (demon) - Shot by Sam with the Colt
- Crossroads Demon - Shot by Sam with the Colt
- Lucy - Decapitated by Dean
- Dixon - Presumably decapitated by Dean
- Gordon's Victim - Shot in the head by Dean with the Colt
- Gordon Walker - Decapitated by Sam with razor wire
- Madge Carrigan - Stabbed by Sam with a stake from an evergreen Christmas tree
- Edward Carrigan - Stabbed twice by Dean with a stake from an evergreen Christmas tree
- Astaroth - Stabbed in the back repeatedly by Dean with the demon-killing knife
- Jeremy Frost - Beaten to death by Sam with a baseball bat in the dream world, killing him in the real world as well
- Dean Winchester - Accidentally killed by Sam with an axe. This was undone due to Gabriel's time loop
- Clark Adams - Back of his head impaled on a metal spike by Sam
- Doc Benton - Trapped in a fridge and buried by Sam and Dean, to eventually turn to dust when his immortality wears off (as he must harvest organs to stay immortal)
- Demon possessing a cop - Stabbed in the throat by Dean with the demon-killing knife
Season 4
- The Witnesses - Put to rest by Dean when he completed a spell performed by Bobby Singer to put the Witnesses to rest.
- Jack Montgomery - Incinerated by Sam with a flamethrower
- Don Harding - Shot in the back by Sam and Dean
- Two Cemetery Zombies - Both staked in the heart with silver stakes.
- Girl in the wall's brother - Shot by Dean
- Dirk McGregor spirit - Destroyed when Dean burned a lock of his hair
- Alastair - Killed by Sam with his power
- P.T. Sandover spirit - Destroyed when Sam burned his gloves
- Kate ghoul - Shot in the head by Dean
- Adam Milligan ghoul - Head beaten in by Dean with a crowbar
- Lilith - Killed by Sam with his power
- Rodger - Throat slit with the demon-killing knife.
- Ruby - Stabbed by Dean with the demon-killing knife while held in place by Sam
Season 5
- Leshii - Decapitated by Sam with an iron axe
- Leticia Gore spirit - Destroyed when Sam and Dean burned her bones
- Karla - Stabbed by Dean with a silver letter opener
- Mrs. Jones (zombified) - Shot in the head by Sam
- Sean Mills (zombified) - Shot in the head by Sam
- Clay Thompson (zombified) - Shot in the head by Dean
- Whore of Babylon - Stabbed by Dean with a stake from a cypress tree
- Zachariah - Stabbed in the throat by Dean with an angel blade
- Zao Shen - Stabbed from behind by Dean with a stake
- Brady - Stabbed by Sam with the demon-killing knife
Season 6
- Lamia - Incinerated by Dean with a flamethrower
- Robert - Decapitated by Dean
- Boris - Decapitated offscreen by Dean
- Veritas - Stabbed by Dean and again by Sam with a knife dipped in dog's blood
- Skinwalker pack leader - Shot in the head by Sam with a silver bullet
- Big Skinwalker - Shot by Dean with a silver bullet
- Fairy - Put in a microwave by Dean, causing it to explode
- Christian Campbell (demon) - Stabbed by Dean with the demon-killing knife
- Hilary - Killed by Dean with his death power, after he refused to do so before causing her to survive her heart condition.
- Arachne - Decapitated by Sam. (a year before the events of the episode)
- Sheriff Roy Dobbs - Decapitated by Sam
- Samuel Campbell - Shot in the head by Sam
- Khan Worm - Electrocuted by Dean with electric cords
- Elias Finch - Shot by Dean with the Colt
- Eve - Bit Dean's neck when he had phoenix ash (her only weakness) in his blood
- Red - Presumably killed by Sam or Dean with the demon-killing knife
- Robin - Shot by Sam (set before the events of the season)
Season 7
- Amy - Stabbed in the heart by Dean
- Osiris - Stabbed in the back by Sam with a ram's horn. He will be revived in centuries
- Kate Fox spirit - Destroyed when Sam burned her bones
- Jimmy Tomorrow - Shot by Sam
- Margaret Fox spirit - Destroyed when Sam burned her bones
- Gerald Browder - Shot multiple times by Sam, Dean, and Bobby
- Marlene - Stabbed by Sam with a silver knife
- Kronos - Stabbed in the heart by Sam with a stake dipped in blood
- Charlene Penn - Shot by Sam
- Emma - Shot by Sam
- Howard - Drowned due to Sam throwing a picture of him drowning and one of his items into a magical fire
- Jeffrey - Shot multiple times by Dean
- Marin's brother's spirit - Destroyed when Sam burned Marin's bracelet which had her brother's blood in it
- Shojo - Stabbed by Dean with a sword
- Whitman's ghost - Destroyed when Dean burned his bones
- Annie's ghost - Body was burned by Sam and Dean so she can rest in peace
- Crane's ghost - Body was burned by Sam and Dean so he can rest in pace
- Bobby Singer's ghost - Destroyed when Dean burned his flask at his request
- Dick Roman - Stabbed in the throat by Dean with the bone of a nun dipped in the blood of Castiel, Crowley, and Alpha Vampire
Season 8
- Demon gardener - Stabbed by Dean with the demon-killing knife
- Demon mailman - Stabbed by Sam with the demon-killing knife
- Eunis (demon) - Stabbed by Dean with the demon-killing knife
- Beau - Hit in the head by Sam with Thor's Hammer
- Mr. Vili - Killed by Sam throwing Thor's Hammer at him
- Randa Moreno - Stabbed in the heart by Dean
- Paul Hayes - Killed when Dean stabbed Randa in the heart, as Brick's heart inside her was what kept those with Brick's organs alive
- Professor Ludensky - Shot by Dean with a silver bullet
- Andrea - Decapitated by Dean
- Viggo - Stabbed by Dean with the demon-killing knife
- Eckhart - Shot in the head by Sam and Dean
- Crowley's Hellhound - Sliced open by Sam with the demon-killing knife
- Spencer - Destroyed by Dean throwing a magic witch-killing molotov at him'
- Benny - Decapitated by Dean so he could go to Purgatory and help get Sam out, and Bobby into Heaven
- Jennifer O'Brien - Stabbed in the back by Dean with a silver knife dipped in lamb's blood
- Jennifer O'Brien's son - Stabbed by Sam with a silver knife dipped in lamb's blood
Season 9
- Maurice - Stabbed in the throat by Dean with an angel blade
- April - Stabbed by Dean with an angel blade
- Sheriff Pat - Silver knife thrown at him by Dean, stabbing him in the heart
- Russ - Stabbed in the back by Dean with a silver knife
- Joba - Stabbed in the back by Dean with a silver knife
- Joy Myers - Shot in the heart by Dean with a silver bullet
- Alonzo - Tongue cut off by Dean with a silver knife
- Roger - Stabbed by Dean with his own knife
- Magnus - Decapitated by Dean with the First Blade
- Mr. Richie - Stabbed by Sam with the demon-killing knife
- Sister Agnes - Stabbed by Sam with the demon-killing knife
- Dale - Decapitated by Dean
- Connor - Decapitated by Dean with the demon-killing knife
- Abaddon - Stabbed by Dean with the First Blade
Season 10
- Lester Morris - Shot by Dean
- Travis - Stabbed in the heart by Sam with a silver knife
- Brandon - Stabbed in the heart by Sam with a silver knife
- Calliope - Stabbed by Sam with a blessed stake
- Scarecrow - Destroyed when Sam killed Calliope
- Olivia - Shot multiple times by Dean with silver bullets
- Salinger - Slashed offscreen by Dean
- Randy - Slashed offscreen by Dean
- Hansel - Stabbed by Dean with a kitchen knife
- Katja - Thrown into her oven by Dean
- Cain - Stabbed by Dean with the First Blade
- Parasitic Khan Worm 1 - Stomped on by Sam
- Parasitic Khan Worm 2 - Stomped on by Dean
- Kit Verson - Shot in the head offscreen by Sam
- Parasitic Khan Worm 3 - Killed offscreen by Sam
- Isabella spirit - Destroyed when Sam burned a portrait containing her finger and blood
- Jacob Styne - Slashed by Sam
- Eli Styne - Throat slit by Dean
- Monroe Styne - Neck broken by Dean
- Roscoe Styne - Stabbed in the back by Dean
- Eldon Styne - Shot in the head by Dean
- Cyrus Styne - Shot in the head by Dean
- Reggie - Decapitated by Dean
- Death - Killed by Dean with his own scythe
Season 11
- Deputy Donnelly - Penny put in his mouth by Dean to remind him he's dead, then decapitated with the door of the Impala
- Marco - Stabbed by Dean with the demon-killing knife
- Chester Johnson's spirit - Destroyed when Sam burned his deer mask, which was the last costume he was tied to
- Richard Beesome - Decapitated by Dean
- Sonja - Shot by Sam with witch-killing bullets
- Qareen - Heart stabbed by Sam with a knife
- Soul Eater - Destroyed when Sam and Dean drew a Soul Eater killing sigil, Sam in the house and Dean in the Soul Eater's nest
- Werewolf that shot Sam - Stabbed in the back by Dean with a silver knife
- Big werewolf - Stabbed by Sam with a silver knife
- Rose - Stabbed by Sam (offscreen, but heard) with a silver knife
- Corbin Tilghman - Shot in the back by Sam with a silver bullet
- Male Bisaan - Some were decapitated by Dean
- Bisaan larva - Burned offscreen by Dean
Season 12
- Hugo Moriarty's spirit - Destroyed when Sam burned his bones
- Wolfgang - Shot in the head by Dean
- Gottfried - Shot in the head by Dean
- Adolf Hitler - Shot in the head by Dean
- Nauhaus - Shot in the head by Dean while possessed by Hitler
- Gideon Loughlin - Shot by Dean with a witch-killing bullet
- Catriona Loughlin - Shot by Dean with a witch-killing bullet
- Boyd Loughlin - Shot by Dean with a witch-killing bullet
- Demon that killed Wally - Stabbed from behind by Dean with an angel blade
- Ramiel - Stabbed by Sam with the Lance of Michael
- Kris - Presumably decapitated by Dean
- Alpha Vampire - Shot in the head by Sam with the Colt
- Ramsay the Hellhound - Stabbed by Sam with an angel blade
- Pete - Shot by Sam
- Moloch - Shot by Sam with the Colt
- Demon Borrower Witch - Shot by Dean with witch-killing bullets
Season 13
- Miriam - Stabbed by Sam with an angel blade
- Sierra - Stabbed from behind by Sam with an angel blade
- Harrington - Angel blade thrown at his neck by Dean
- Wraith (Patience) - Stabbed by Dean with a silver blade
- Buddy - Shot by Sam with a silver bullet
- Dr. Avery Meadows (ghost) - Destroyed when Dean burned his masks
- Clegg - Shot in the back by Dean
- Magog - Decapitated by Dean with his own sword
- Gog - Stabbed from behind by Dean with Magog's sword
- Mr. Cromarty - Shot by Sam
- Ghost Kid - Put to rest when Sam burned the knife he was tied to
- Bernard - Strangled by Dean
- Angel commander - Stabbed by Dean with an angel blade
- Lucifer - Stabbed by Dean with an archangel blade, powered by Alternate Michael